Protocolsnutrition
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Adrenal Recovery Protocol (HPA Axis Restoration)

Comprehensive protocol to restore hypothalamic-pituitary-adrenal (HPA) axis function after chronic stress.

Evidence Score

79/100

Developer

James Wilson, Alan Christianson

Duration

6-12 months for significant HPA recovery, up to 2 years for complete restoration

Steps

15 phases

Conditions

5 targeted

Protocol Overview

Comprehensive protocol to restore hypothalamic-pituitary-adrenal (HPA) axis function after chronic stress. Addresses "adrenal fatigue" (controversial term) through evidence-based HPA support.

Conditions Treated

Adrenal fatigueHPA axis dysfunctionchronic stressburnoutcortisol dysregulation

Key Resources

Adrenal Fatigue by James Wilson, "The Adrenal Reset Diet" by Alan Christianson, functional medicine protocols, DUTCH test

Safety Profile

Contraindications & Risks
Licorice raises blood pressure (avoid if hypertensive), stimulating adaptogens contraindicated in high cortisol phase
Important Notes

Adrenal fatigue is controversial term (mainstream endocrinology rejects it, but HPA axis dysfunction is real). Adrenal glands don't "fatigue" but HPA axis becomes dysregulated from chronic stress. Classic pattern: Initially high cortisol (stressed, wired), eventually low/flat cortisol (burnout, exhaustion). Salivary cortisol shows daily rhythm (should be high AM, decline during day, low at night). Many have reversed pattern. Sleep is #1 intervention - cortisol rhythm set by sleep/wake. Blood sugar swings stress HPA axis. Adaptogens are intelligent - rhodiola/licorice for low cortisol, phosphatidylserine/holy basil for high cortisol, ashwagandha modulates both directions. Exercise is double-edged: moderate exercise healthy, overtraining worsens HPA dysfunction. Recovery takes time (months to years). Biggest challenge: reducing life stress. Pregnenolone is "mother hormone" - gets shunted to cortisol under stress (pregnenolone steal), depleting sex hormones.

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EvidenceModerate
Evidence Score79/100
Categorynutrition
Duration6-12 months for significant HPA recovery, up to 2 years for complete restoration

About Evidence Score

The Evidence Score rates the strength of clinical and scientific evidence behind this protocol. Higher scores indicate stronger research support. This is a research tool, not medical advice.

Educational purposes only. Some alternative protocols carry serious risks. Always consult qualified healthcare professionals before beginning any treatment.